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Antonio Rosas; Paleoanthropology Group MNCN-CSIC More Self-medication One of the Neanderthals at El Sidron wasn't in good health: The hominin had a dental abscess (a painful tooth infection) and a diarrhea-causing intestinal parasite. However, the individual was self-medicating, the dental plaque analysis indicated. The individual's plaque showed evidence of poplar a tree that contains the natural painkiller salicylic acid, aspirin's active ingredient as well as DNA sequences of a natural antibiotic found in mold, the researchers found. "Apparently, Neanderthals possessed a good knowledge of medicinal plants and their various anti-inflammatory and pain-relieving properties, and seem to be self-medicating," Cooper said. " The use of antibiotics would be very surprising, as this is more than 40,000 years before we developed penicillin. Certainly our findings contrast markedly with the rather simplistic view of our ancient relatives in popular imagination." Mouth bacteria The scientists also examined the Neanderthals' mouth bacteria, known as the oral microbiome, and compared the results with oral bacteria from other groups. The oral microbiome of the El Sidron Neanderthals was more similar to that of chimpanzees and foraging human ancestors from Africa, while the Spy Cave Neanderthals' mouth bacteria looked more like those from early hunters and gatherers and modern humans, the researchers found. "Not only can we now access direct evidence of what our ancestors were eating, but differences in diet and lifestyle also seem to be reflected in the commensal bacteria that lived in the mouths of both Neanderthals and modern humans," study co-author Keith Dobney, a professor of human paleoecology at the University of Liverpool in the United Kingdom. [ Microbiome: 5 Surprising Facts About the Microbes Within Us ] In addition, one of the El Sidron individuals had the near-complete genome of Methanobrevibacter oralis, an oral bacterium that causes cavities and gum disease. At 48,000 years old, the specimen is the oldest draft microbial genome on record, the researchers said.